Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns.
نویسندگان
چکیده
Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.
منابع مشابه
AMERICAN ACADEMY OF PEDIATRICS Newborn Screening for Congenital Hypothyroidism: Recommended Guidelines
Congenital hypothyroidism (CH) represents one of the most common preventable causes of mental retardation. The fetal hypothalamic-pituitary-thyroid axis begins to function by midgestation and is mature in the term infant at delivery. If fetal hypothyroidism develops, untoward effects may be demonstrated in certain organ systems, including the central nervous system and skeleton. However, most i...
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عنوان ژورنال:
- The Southeast Asian journal of tropical medicine and public health
دوره 34 Suppl 3 شماره
صفحات -
تاریخ انتشار 2003